EN | UA
EN | UA

Help Support

Back

New insights: Nutrition and genetic variations in preventing childhood atopic dermatitis

Pregnancy supplementation, Childhood atopic dermatitis Pregnancy supplementation, Childhood atopic dermatitis
Pregnancy supplementation, Childhood atopic dermatitis Pregnancy supplementation, Childhood atopic dermatitis

What's new?

Effectiveness of prenatal fish oil or omega supplementation in reducing early-onset atopic dermatitis risk depends on the mother's COX1 genotype, implying that personalized supplementation based on genetic testing could be more effective.

A recent analysis from a major Danish study, published in the renowned journal - JAMA Dermatology has unveiled intriguing findings into how prenatal fish oil supplements, combined with genetic factors, may influence the risk of atopic dermatitis (AD) in children. The study, part of the Copenhagen Prospective Studies on Asthma in Childhood, included nearly 635 mother-child pairs, with children tracked from birth to age 10 to uncover how prenatal nutrition and genetics intersect in AD development.

The research by Liang Chen and colleagues focused on 736 pregnant women, half of whom took daily fish oil supplements rich in n-3 long-chain polyunsaturated fatty acids (LCPUFAs) from 24 weeks of pregnancy until shortly after childbirth. The other half received a placebo (49%). Urinary eicosanoids and genetic variations related to the cyclooxygenase-1 (COX1) pathway were analyzed.

Prenatal n-3 LCPUFA supplementation lowered urinary thromboxane A2, with varying effects based on COX1 genotype. For mothers with the TT genotype, it reduced childhood AD risk, while it had no effect on the CT genotype and increased the risk for the CC genotype.

This indicated a significant interaction between n-3 LCPUFA intake and maternal COX1 genotype in AD risk. Interestingly, the overall connection was not noteworthy between fish oil use alone and AD risk across the entire cohort. However, the outcomes recommend that the benefits of fish oil may be influenced by maternal genetic factors, highlighting the importance of personalized prenatal nutrition, concluded Liang Chen.

Source:

JAMA Dermatology

Article:

Prenatal Fish Oil Supplementation, Maternal COX1 Genotype, and Childhood Atopic Dermatitis

Authors:

Liang Chen et al.

Comments (0)

You want to delete this comment? Please mention comment Invalid Text Content Text Content cannot me more than 1000 Something Went Wrong Cancel Confirm Confirm Delete Hide Replies View Replies View Replies en
Try: