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The
preemptive IV administration of both ibuprofen and paracetamol during open
septorhinoplasty exhibit positive effects, although, the overall efficacy of ibuprofen
is superior.
According to a randomised
controlled study published in the European Archives of Oto-Rhino-Laryngology,
Ibuprofen reflects better efficacy in reducing postoperative pain and opioid
consumption than paracetamol after open septorhinoplasty. Septorhinoplasty is a
procedure involved septoplasty along with rhinoplasty. Patients felt severe
pain after the septorhinoplasty surgery.
The study involved administration of intravenous(IV) Ibuprofen and IV
Paracetamol to lessen pain and opioid intake after the surgery. A total of 150
participants were included in the analysis which was equally divided into three
groups; group control, group Ibuprofen and group Paracetamol. The group P
obtained 1000mg Paracetamol in 100ml solution; group I got 800mg Ibuprofen in
100ml saline, and group C, i.e. the control group administered with 100 ml
saline before the procedure. The opioid was administrated through
patient-controlled analgesia to attained relief from postoperative pain. The
postoperative opioid intake, visual analog score (VAS) scores for pain, need
for additional analgesia, and adverse events were noticed after the therapy.
The VAS scores and consumption of opioids were statistically lower among group
P and the group I as compared to the control group (p < 0.05). Out of group
P and I, group I showed lower VAS scores at 1st and 6th hours after the surgery
(p < 0.05). The group I also exhibited reduced total opioid intake than
group P at 6th and 12th hours (p < 0.05). Group C showed the highest total
opioid intake (p < 0.05). However, after 12 hrs, a non-inferiority is
noticed among Ibuprofen and Paracetamol. Overall results indicated impact of
Ibuprofen is better than Paracetamol in all aspects at first 12 hours.
European Archives of Oto-Rhino-Laryngology
The comparison of single-dose preemptive intravenous Ibuprofen and Paracetamol on postoperative pain scores and opioid consumption after open septorhinoplasty: a randomized controlled study.
Erkan Cem Çelik et al.
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