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OA patients should be assessed for oxidative stress and metabolic
disturbances as increased levels of OxS, decreased antioxidant capacity,
impaired lipid metabolism and dysglycemia were found in end-stage OA patients.
A recent study revealed that impaired lipid metabolism and
dysglycemia were linked to OA. The results obtained from the study revealed the
significance of OxS and metabolic disturbances in the pathogenesis of OA. Cartilage
loss as a result of the joint disease leads to osteoarthritis (OA or
degenerative arthritis). It causes pain and stiffness in the affected joint.
According to previous studies, metabolic disturbances might be involved in the
development of osteoarthritis (OA). This was explained on the basis of
relationship drawn between the individual components of metabolic syndrome
(MetS) and OA. MetS have been associated with escalated oxidative stress (OxS).
The study was executed to elucidate the role of MetS components in OA and to
investigate the levels of OxS in OA patients and in age-matched controls. All
in all, 55 patients with end-stage OA of 63 ± 7 years of age prior to hip or
knee joint replacement surgery and 55 age-, gender- and BMI-matched controls
(61 ± 8 years) were included in the study. Serum levels of cholesterol,
glucose, insulin, c-peptide, and OxS markers were noted. The proxy measure of
insulin resistance was evaluated using the homeostasis model. The
Kellgren-Lawrence score was used to estimate the radiographic severity.
It was found that the OA patients had elevated total peroxide concentration and
oxidative stress index and lowered total antioxidant capacity compared with the
controls. Also, notable higher levels of C-peptide were observed in the OA
group as compared to the controls. Moreover, OA radiography was independently
concerned with LDL-cholesterol (p = .007) and oxidized LDL (p = .022). The
end-stage OA patients had higher levels of OxS and lowered antioxidant
capacity.
Scand J Clin Lab Invest. 2017 Jul 24:1-7
Metabolic factors and oxidative stress in osteoarthritis: a case-control study
Tootsi K. et al.
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