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In patients with gingivitis, the antibacterial properties of stannous fluoride dentifrice can help to reduce endotoxins, oxidative products, and gingival inflammation.
In a prospective clinical trial by Niranjan Ramji and other researchers, the use of stannous fluoride (SnF2) dentifrice reversed gingival inflammation, lowered endotoxins, and decreased harmful oxidants in saliva and gums. This study published in “BMC Oral Health” explored the influence of SnF2 on oxidative stress in gingivitis-affected adults. In this 2-month study, 20 adults with gingivitis and 20 healthy adults used SnF2 toothpaste twice daily.
At baseline, first month, and second month, oral exams, along with Modified Gingival Index (MGI) and Gingival Bleeding Index (GBI) assessments were executed. At every consultation, collection of gingival crevicular fluid, saliva, oral lavage, and supragingival plaque was done. This was carried out to measure C-reactive protein (CRP), endotoxins, protein carbonyls, L-lactate dehydrogenase, ferric reducing antioxidant power (FRAP), interleukin-6, and oxidized low density lipoproteins (oxi-LDL).
A subset assessment focused on subjects at higher cardiovascular disease risk. The primary focus was on alteration from baseline assessment within each group. In the gingivitis group, SnF2 use led to substantial improvements, with GBI dropping by 67% at first month and 85% at second month. MGI also dropped by 36% at first month and 51% at second month when compared to the starting point. At baseline, the disease group exhibited higher levels of L-lactate dehydrogenase in gingival crevicular fluid and oxi-LDL in saliva as opposed to the healthy group.
For the disease group, the total antioxidant capacity (FRAP) in saliva escalated at first and second months and was higher than in the healthy group at both time points. SnF2 use lowered endotoxin levels in lavage for both groups by the second month compared to baseline. There was also a decrease in oxidative stress markers, such as protein carbonyl in saliva at first and second months for both groups, and a drop in cytokine interleukin-6 in lavage for the disease group at second month.
In a subset assessment of subjects at heightened risk for coronary disease, there was a decrease in endotoxins in lavage, oxi-LDL, and CRP in saliva by second month. Thus, SnF2 toothpaste effectively reduces gum inflammation, harmful bacteria, and oxidative stress, making it a valuable tool for managing gingivitis and potentially benefiting those at higher cardiovascular risk.
BMC Oral Health
Effects of stannous fluoride dentifrice on gingival health and oxidative stress markers: a prospective clinical trial
Niranjan Ramji et al.
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