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A minimally invasive second-generation endometrial ablation is a new alternative to manage treatment-resistant
menorrhagia or dysmenorrhea.
As per new findings, postoperative
administration of dienogest along with microwave endometrial ablation helps to
alleviate symptomatic adenomyosis. Adenomyosis affects about 5 to 70 % of the
population and manifests with issues like menorrhagia and dysmenorrhea. All these
together leads to reduce female's quality of life. To manage this severe
problem, Microwave endometrial ablation (MEA) is the treatment of choice. The
MEA involves womb ablation to stop complications like menorrhagia. Also, a drug
Dienogest is used to decrease dysmenorrhea by terminating endometrium. But some
patients show resistance against dienogest.
Kuniaki Ota and colleagues conducted a trial to analyse the effect of a
combination, microwave endometrial
ablation along with postoperative Dienogest therapy in adenomyosis and related
symptoms management. A total of ten patients who were resistant to hormone
treatment went through MEA and received oral Dienogest after surgery. The
anaemia and pain recurrence was taken as primary endpoints. Change in adenomyosis
and related symptoms recurrence were considered as secondary endpoints.
The haemoglobin levels and visual analog scale (VAS) scores improved
significantly after the treatment. A statistically significant change was also
noticed in myometrial thickness after the surgery. No symptomatic recurrence
was seen. The results reflect that the combined treatment shows a considerable
relief from both pain and bleeding.
J Obstet Gynaecol Res
Combination of microwave endometrial ablation and postoperative Dienogest administration is effective for treating symptomatic adenomyosis.
Kuniaki Ota et al.
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