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While laparoscopic surgery is useful for treating deep endometriosis, the optimal postoperative management remains debated. This open-label, randomized controlled trial investigated whether using Dienogest after surgery can boost fertility and alleviate menstrual discomfort in infertile women.
In infertile women with deep endometriosis, Dienogest as an add-on therapy is more effective than surgical intervention alone in improving pregnancy rates and dysmenorrhea severity.
While laparoscopic surgery is useful for treating deep endometriosis, the optimal postoperative management remains debated. This open-label, randomized controlled trial investigated whether using Dienogest after surgery can boost fertility and alleviate menstrual discomfort in infertile women.
Overall, 88 women (age 21-38 years) who underwent surgery for deep endometriosis were enrolled. Three patients did not complete follow-up assessments. After surgery, participants were randomly assigned to two groups: 44 women received Dienogest for three months (Group 1), while 41 women received no treatment (Group 2). The primary endpoint was the pregnancy rate measured nine months post-surgery. The secondary endpoint was menstrual pain intensity assessed before and nine months after surgery.
The pregnancy rate in Group 1 was markedly greater than in Group 2 Additionally, women in Group 1 reported a better reduction in dysmenorrhea intensity when compared to Group 2, as shown in Table 1:
Short-term postoperative use of dienogest (selective progestin) was associated with improvements in spontaneous pregnancy rates and dysmenorrhea severity in infertile patients with deep endometriosis.
Ginekologia Polska
Efficacy of postsurgical medical therapy for infertile patients with deep endometriosis
David Skhirtladze et. al.
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