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Effect of Omeprazole on fat absorption in cystic fibrosis patients

Cystic fibrosis Cystic fibrosis
Cystic fibrosis Cystic fibrosis

A study with random cross-over design examined the impact of Omeprazole (proton-pump inhibitor) on fat absorption in cystic fibrosis people with residual steatorrhoea.

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Key take away

Omeprazole reduces residual steatorrhoea in children with cystic fibrosis receiving large doses of pancreatic enzyme supplementation.

Background

A study with random cross-over design examined the impact of Omeprazole (proton-pump inhibitor) on fat absorption in cystic fibrosis people with residual steatorrhoea.

Method

In total, 24 people with cystic fibrosis who still had persistent symptomatic steatorrhoea despite a daily high dose of at least 10,000 U lipase/kg per day (pancreatic enzymes) were candidates for the study. Chemical fat measures in 3-day stool collections along with 3-day weighted meal records for calculating fat absorption were used to compare fat digestion with and without Omeprazole.

Result

During the control evaluation, the outcomes of 15 subjects (12 boys and 3 girls) with confirmed steatorrhoea were examined. The median age was 8.7 years and the age range was 3.5 to 15.9 years. The median daily lipase intake was 13,500 U/kg/day (range 10,000–22,000 U/kg).

The median fecal fat loss per day when taking Omeprazole reduced from 13 g (quartiles 11.5-16.5 g/day) to 5.5 g (quartiles 4.9-8.1 g/day). Calculation of fat absorption revealed a similar improvement: 94% (quartiles 90-96%) with Omeprazole compared to 87% (quartiles 81-89%) without Omeprazole.

Conclusion

Omeprazole enhances fat digestion and absorption in individuals having cystic fibrosis with residual fecal fat loss despite the maximal substitution of pancreatic enzymes.

Source:

European Journal of Pediatrics

Article:

Omeprazole, a proton pump inhibitor, improves residual steatorrhoea in cystic fibrosis patients treated with high dose pancreatic enzymes

Authors:

Marijke Proesmans et al.

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