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Polyunsaturated fatty acids (PUFAs), members of the family of fatty acids play a pivotal part in the homeostasis of the immune system: n-3 PUFAs exert pro-resolving and anti-inflammatory properties, whereas n-6 PUFAs exert predominantly pro-inflammatory characteristics.
Many studies evaluate the relationship between Polyunsaturated fatty
acids (PUFAs) and rheumatoid arthritis (RA) but none of them provide information about n-3 PUFAs enriched daily products
supplementation and the incidence of the disease in high risk population. Therefore,
this meta-analysis demonstrates that 3 PUFAs rich supplementation could be a
therapeutic option to better control of RA.
Polyunsaturated fatty acids (PUFAs), members of the
family of fatty acids play a pivotal part in the homeostasis of the immune
system: n-3 PUFAs exert pro-resolving and anti-inflammatory properties, whereas
n-6 PUFAs exert predominantly pro-inflammatory characteristics. Investigation
about PUFAs could describe a vital opportunity to decipher the pathogenesis
better and to enhance the RA management.
CENTRAL, Wanfang, PubMed,
CNKI, EBSCO-Medline, and Embase were searched till March 2017 o
recognise primary examination describing the use of n-3 PUFAs in rheumatoid
arthritis both in humans and in animal models.
Information from animal models supports the hypothesis
that n-3 PUFAs present an intriguing prospect in the future investigation as
much in prevention as in treating RA. In humans, numerous prospective cohort
and case-control studies propose that a high content of n-3 PUFAs in the diet
could present a protective role for incident RA among the participants who were
at risk. Also, n-3 PUFAs supplementation has been evaluated as an important
therapeutic alternative for participants with RA, mainly to improve the tender
joint count, the rate of intake of NSAIDs, the span of morning stiffness, and
the pain symptoms.
n-3 PUFAs supplementation could serve a promising
therapeutic alternative to manage many manifestations of RA properly. The
influence of n-3 PUFAs on synovial histopathology and radiographic progression
is still not estimated, as well as their use in the combination with biologics
and early arthritis.
Lipids Health Dis. 2017 Oct 10;16(1):197
Polyunsaturated fatty acids: any role in rheumatoid arthritis?
Luca Navarini et al.
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