Preemptive analgesia in periodontal surgeries: Efficacy of Dexamethasone, Etoricoxib and Ketorolac

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Created On: 17/10/2024

Periodontal surgeries are known to cause significant postoperative pain. A systematic review evaluated whether prophylactic pain control using steroidal and non-steroidal anti-inflammatory drugs (NSAIDs) could better manage this pain and improve recovery.

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Key take away

Preemptive oral analgesia with certain steroids and NSAIDs significantly reduces postoperative pain in periodontal surgeries.

Background

Method

Investigators searched multiple databases, including Cochrane CENTRAL, MEDLINE, EMBASE, and Web of Science for relevant randomized clinical trials (RCTs). Six RCTs with 250 participants were included. Primary outcomes assessed were postoperative pain, edema, and trismus, with a narrative synthesis of the findings.

Result

Despite elevated risks of bias, especially in randomization masking, the preventive usage of Dexamethasone (8 mg), Etoricoxib (90 mg or 120 mg), and Ketorolac (20 mg) was found to be highly useful at attenuating postoperative pain compared to placebo.

Conclusion

Drugs like Dexamethasone, Etoricoxib, and Ketorolac proved to be useful for addressing postoperative pain in periodontal surgeries. However, due to methodological limitations and the need for more comprehensive studies, further research is warranted to substantiate their safety and effectiveness.