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Current investigations have shown a relationship among a migraine and restless legs syndrome (RLS), although the prevalence of RLS amongst people with migraine varies considerably across the investigations.
Restless legs syndrome also
known as Willis-Ekbom disease is a common neurological sensorimotor disorder
that causes an overwhelming, irresistible urge to move the legs. The following
meta-analysis of the observational studies provide strong evidence that
restless legs syndrome has higher risk among individuals with a migraine than
among controls.
Current investigations have
shown a relationship among a migraine and restless legs syndrome (RLS),
although the prevalence of RLS amongst people with migraine varies considerably
across the investigations. The study aimed to estimate present evidence to
determine RLS predominance amidst subjects with migraine and non-migraine
controls.
The Embase, SinoMed, Web of
Science, Wanfang, Chinese National Knowledge Infrastructure, and PubMed
databases were examined for case-control and observational and studies of RLS
prevalence amongst migraineurs. Stata 12.0 software was used to conduct a
meta-analysis of the eligible studies.
The prevalence of RLS in
migraine was observed to be 19% with the lower incidence rate in Asia and
outside Asia (16 and 21%, respectively). The migraineurs with aura showed 18.8%
of RLS prevalence and migraineurs
without aura showed 18.5% of RLS
prevalence. Moreover, migraineurs exhibited higher pooled RLS prevalence in a
case-control study as compared to non-migraine controls.
The meta-analysis presents the first positive pooled assessment of RLS prevalence amongst people with migraine, and it gives strong evidence that RLS risk is greater among migraineurs as compared to controls.
Neurological Sciences
Prevalence of restless legs syndrome in individuals with migraine: a systematic review and meta-analysis of observational studies
Xinglong Yang et al.
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