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The objective of the study was to estimate the relationship between the gastrointestinal disorders and risk of further RA) development.
The present study showed an intersting link
between the chronic diarrhea and the risk of furher RA development and that too
mainly among ever-smokers.
The objective of the study was to estimate the relationship
between the gastrointestinal disorders and risk of further RA) development.
The french prospective cohort included
98995 healthy women since 1990. The questionnaires related to health information
and lifestyles were completed by all the participants. In 1993, the third
questionnaire was sent to the participants for estimating gastrointestinal
disorders. Cox proportional hazards regression model with age as the time scale
was utilized to find the hazard ratio and 95% CIs for incident RA. The models
were adjusted for age, known risk factors of RA like smoking and possible
cofounders.
Out of the 65454 cases, five hundred thirty
proved incident RA cases were diagnoses post 11.7 years of the study baseline.
Compared to patients with no gastrointestinal problems, chronic diarrhea was
found to be linked with a higher risk of RA development, independently of
dietary habits or dysthyroidism. Also, the association was even stronger in
ever-smokers. However, there was no link between the risk of RA and
constipation or alternating constipation/diarrhea.
A significant association was noted between
chronic diarrhea and increased risk of further development of RA, mainly among
ever-smokers. These findings go well with the mucosal origin hypothesis of RA,
where an early association between smoking and intestinal imbalance has been
noted to increase the emergence of autoimmunity, resulting in the development
of clinical disease at a later stage.
Rheumatology (Oxford, England)
Chronic diarrhoea and risk of rheumatoid arthritis: findings from the French E3N-EPIC Cohort Study.
Nguyen Y et al.
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