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Regarding the use of intravenous lidocaine in fibromyalgia, there are no well-controlled studies.
Lidocaine/xylocaine/lignocaine
is a drug used to numb the tissue in a specific area or loss of feeling for the
patients who are undergoing medical procedures. The role of lidocaine combined
with amitriptyline for analgesic efficacy has been studied efficiently here in
this article.
Regarding the use
of intravenous lidocaine in fibromyalgia, there are no well-controlled studies.
This study aimed to evaluate the effect of intravenous lidocaine on pain
intensity, clinical manifestations and plasma levels of interleukin (IL)-1,
IL-6, and IL-8 in fibromyalgia patients.
In a randomized
double-blind study, group 1 patients received 240 mg of lidocaine in 125 mL of
saline solution, while group 2 patients received 125 mL of saline, both once a
week for 4 weeks (T1, T2, T3 and T4). All patients received amitriptyline. The
following were assessed: pain intensity before treatment (T0) and at 1, 2, 3, 4
and 8 weeks after treatment; clinical manifestations; the fibromyalgia impact
questionnaire (FIQ) before and at 4 and 8 weeks after; the levels of IL 1, 6
and 8 before and at 4 and 8 weeks after treatment.
Lower pain
intensity was observed in the lidocaine group at T2, with no difference at the
other time points. There was a reduction in pain intensity in both groups. The
use of paracetamol and tramadol and plasma levels of IL-1, IL-6 and IL-8 did
not differ between the groups. Clinical manifestations and side effects did not
differ between groups.
The combination
of 240 mg of intravenous lidocaine (once a week for 4 weeks) with 25 mg of
amitriptyline for 8 weeks had no meaningful impact in fibromyalgia patients.
International journal of rheumatic diseases
Effect of intravenous lidocaine combined with amitriptyline on pain intensity, clinical manifestations and the concentrations of IL-1, IL-6 and IL-8 in patients with fibromyalgia: A randomized double-blind study
Ana Laura Albertoni Giraldes et al.
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